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KMID : 0988420030150010083
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Journal of Dental Science (C.N.U.)
2003 Volume.15 No. 1 p.83 ~ p.92
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Nitric Oxide on the MMP-2 Expression by Human Gingival Fibroblast
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Abstract
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Periodontitis are infectious diseases characterized by periodontal attachment loss and bone destruction. Various collagens, the predominant extracellular matrix (ECM) components of periodontium which produced by periodontal ligament and gingival fibroblasts, are the main targets of degradation in periodontitis. Among host proteases degrading the extracellular matrix, matrix metalloproteinases (MMPs) are highly related to tissue destruction and remodeling events in periodontal diseases. The initial split of gingival and periodontal ligament collagens is a key feature of progressive and active periodontitis lesions or pockets, and this initial cleavage is carried out by the host cell-derived MMPs. It has been suggested that increased number and activity of phagocytes in periodontitis lesion results in a high degree of reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, nitric oxide, peroxynitrite. There are few reports on the relationship between ROS and MMPs expressions in gingival fibroblast.
This study showed that, especially nitric oxide, could be the critical mediator of periodontal disease progression through control of MMP-2 expression in gingival fibroblast possibly via Ras/NF-kappa B pathway.
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